Prodn. of aq. dispersions of lipid spherules - by forming lamellar phase from lipid and aq. phase for encapsulation then shaking with dispersing liq.

摘要

Process for forming a dispersion of spherules comprising organised molecular layers contg. an encapsulated aqueous phase comprises (a) mixing (i) a water-dispersible, liq. lipid having a nonionic or ionic hydrophilic portion and a lipophilic portion adn of HLB value such that it swells in the encapsulated aqs. phase, ith (ii) the aqueous phase to be encapsulated; (b) stirring to form a lamellar phase; and (c) addig a dispersing liq. in amt. greater than that of the lamellar phase and vigorously shaking for 15 min. to 3 hrs. Process is esp. used for encapsulation of cosmetic agents such as artificial tanning agents, sunscreen agents, antiperspirants, deodorants, depilatories, antiserborrhoeics etc., or a foodstuff or pharmaceutical agent such as vitamins, hormones, enzymes, vaccines, antiinflammatories, e.g. hydrocortisone, antibiotics and bactericides.