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Steroids in the 10-position is substituted with aryl, aralkyl, arylthio, alkenyl or alkynyl, and pharmaceutical composition containing the compounds
Steroids in the 10-position is substituted with aryl, aralkyl, arylthio, alkenyl or alkynyl, and pharmaceutical composition containing the compounds
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机译:在10位的类固醇被芳基,芳烷基,芳硫基,烯基或炔基取代,并且含有该化合物的药物组合物
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摘要
A novel steroid of the formula IMAGE I wherein X is methylene and R is an optionally substituted carbocyclic aryl or heterocyclic aryl or optionally substituted vinyl or ethynyl or X is a simple bond or -S- and R is optionally substituted carbocyclic aryl or heterocyclic aryl, R2 is methyl or ethyl, R3 is selected from the group consisting of optionally substituted alkyl of 1 to 8 carbon atoms and optionally substituted alkenyl and alkynyl of 2 to 8 carbon atoms, R4 is selected from the group consisting of hydrogen and acyl, IMAGE is selected from the group consisting of IMAGE R6 is selected from the group consisting of hydrogen and methyl, the wavy line indicates alpha or beta - and the dotted line in 1(2) indicates the optional presence of a second carbon-carbon bond and novel process and intermediates therefore having anti-glucocorticoid activity.
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