Therapeutically active 4- (3-methylflavone-8-yl) -1,4-dihydropyridine derivatives, fremgangsnmåder for their preparation and to pharmaceutical compositions containing them

摘要

New flavone derivatives of general formula: …CHEM… wherein R and R1 can be equal or different and are alkyl containing from 1 to 4 carbon atoms, hydroxyalkyl having 1-4 carbon atoms, formylalkyl or cyanoalkyl, R2 and R3 could be equal or different and are straight or branched alkyl containing from 1 to 6 carbon atoms, straight or branched alkenyl containing from 2 to 6 carbon atoms, alkynyl containing from 2 to 6 carbon atoms, cycloalkyl having 5-7 carbon atoms, aralkyl, phenyl, cyanoalkyl, haloalkyl, mono- or poly-hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkylsulfonylalkyl, acyloxyalkyl, acylalkyl, R4R5N-alkyl straight or branched having 2-6 carbon atoms, where R4 and R5 are equal or different and are hydrogen, alkyl, cycloalkyl, aralkyl, phenyl, 3,3-diphenylpropyl, or alternatively, together with the nitrogen atom they form a satured or unsatured 4-7 membered ring, containing other heteroatoms, like O, N or the NR6 group wherein R6 is alkyl, their optical isomers and diastereoisomers, and pharmaceutically acceptable salts thereof. …??The compounds of general formula (I) exhibit a calcium-antagonistic activity and/or an activity relaxing the smooth musculature (in particular the bladder). …??Some procedures for their preparation, and the pharmaceutical composition containing a derivative of general formula (I) as active constituent, are also described.