now we're going to estradiolderivat - klorambucil - konjugat, foerfarande foer dess framstaellning och farmaceutiska kompositioner

摘要

An estradiol derivative-chlorambucil conjugate of the formula (I): CHEM wherein R1 is alkyl or alkoxyl of 1 to 4 carbon atoms; R2 is acyl, dansyl, or alkyl; R3, R4, and R5 independently are H, oxo, OH, or acyloxy; m is an integer of 1 to 3; and n is an integer of 0 to 3; provided that when n is 0, all of R3, R4, and R5 are not H at the same time, and at least one of R3, R4, and R5 is a group other than H and OH; and further, when n is 2 or 3, the groups R1 are the same or different; a process for preparing the same, and a pharmaceutical composition containing the conjugate are described.