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methods for regulating the immune response, using the ctla4: er binding molecules, and il4: er binding molecules
methods for regulating the immune response, using the ctla4: er binding molecules, and il4: er binding molecules
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机译:ctla4:er结合分子和il4:er结合分子调节免疫应答的方法
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摘要
The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
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