METHOD FOR RADIOIMMUNOLOGIC DETECTION OF 9-DEOXY-DELTA 9,12, 13,14-DIHYDRO-PROSTAGLANDIN D2 /DELTA 12-PGY2/ CONTENT AND PRODUCTION OF RADIOLIGAND TRACED BY IODINE-125 ISOTOPE USED IN THE SAME METHOD

摘要

Radio-ligand delta-twelve-PGJ2-mono-iodo- tyrosine-methyl-ester of formula (I) is prepd. from delta, twelve-PGJ2-tyrosine-methyl-ester (II) and Na 125I of exceptionally high specific activity. - Application of radio-ligand (I) improved radio-immunological assaying of 9-dezoxy-delta,mine-13,14- di:hydro-prosta-glandin O2 (delta, twelve-PGJ2) content of sample-specimens owing to high specific activity of 125I tracer, the sensitivity level of the delta, based, on an antiglow-antibody immune-chemical bond forming reaction is few tenth of a picoamp. This invention establishes favourable condns. for prepn. of radio-ligand (I). - (Dwg.-)