SUBSTITUTED BENZOYL-GUANIDINE DERIVATIVES, PROCESS FOR PRODUCING THEM, USE OF THEM FOR INHIBITING CELLULAR NA+/H+ EXCHANGE AND PHARMACEUTICAL AND DIAGNOSTICAL COMPOSITIONS CONTAINING THEM

摘要

There are described benzoylguanidines of the formula I IMAGE where R(1) to R(3) are H, Hal, (cyclo)alkyl, N3, CN, or OH, alkyloxy, phenyl, phenoxy or benzoyl, and their pharmacologically acceptable salts, but with the exception of the compounds benzoylguanidine, 4-chlorobenzoylguanidine, 3,4-dichlorobenzoylguanidine and 3- or 4-methylbenzoylguanidine. They are obtained by reaction of a compound II IMAGE where L is a leaving group, with guanidine.t