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NEW BENZOCYCLOHEPTIENES, AND BENZOXEPINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PRODUCING THEM

机译:新的苯环庚类和苯佐西汀,包含它们的药物组合物及其制备方法

摘要

PCT No. PCT/EP93/03445 Sec. 371 Date Aug. 5, 1994 Sec. 102(e) Date Aug. 5, 1994 PCT Filed Dec. 7, 1993 PCT Pub. No. WO94/13658 PCT Pub. Date Jun. 23, 1994The subject of the invention is compounds of general formula: IMAGE I in which: X represents O or CHR, R1, R2, R3 and R4, which are identical or different, represent a hydrogen atom or a C1-C7 alkyl group, it being possible for R1 to additionally form a bond with R; R5 represents a hydrogen atom, a hydroxyl group or R5, taken together with R7, forms a bond or a O; group; R6 represents a group of formula: IMAGE in which R10 and R11, taken together with the carbon atom to which they are attached, form a nitrogenous heterocyclic group, and their N-oxides and pharmaceutically acceptable salts. These compounds are powerful activators of potassium channels.
机译:PCT号PCT / EP93 / 03445 371日期1994年8月5日第102(e)日期,1994年8月5日,PCT,1993年12月7日,PCT公开。 WO94 / 13658 PCT公开号日期:1994年6月23日,本发明的主题是通式: I的化合物,其中:X表示O或CHR,R1,R2,R3和R4相同或不同,表示氢原子或C1 -C7烷基,R1可以与R另外形成键; R 5代表氢原子,羟基或R 5与R 7一起形成键或> O;组; R 6表示式:,其中R 10和R 11与它们所连接的碳原子一起形成含氮杂环基,及其N-氧化物和药学上可接受的盐。这些化合物是钾通道的强大活化剂。

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