Modified human tissue-type plasminogen activator devoid of functional carbohydrate structure at amino acid residue 117 having increased in vivo half-life, its preparation and pharmaceutical composition containing said molecule

摘要

Disclosed are various novel human tissue-type plasminogen activators characterised by having a modified carbohydrate structure at amino acid residue 117. Means for their preparation and results of assays measuring function of the activators are also disclosed.