COMPOSITIONS FOR PARENTERAL TREATMENT OF VISCERAL LEISHMANIASIS COMPRISING PAROMOMYCIN OR DERIVATIVES OR SALTS THEREOF, OPTIONALLY

摘要

A compound of formula (I), wherein R1 is a hydroxy group or an amino group optionally substituted with a C1-C4 alkyl or phenyl-(C1-C4)alkyl group, R2 is hydrogen or a hydroxy group, R3 is hydrogen or chlorine, R4 is hydrogen or a hydroxy or amino group, R5 is hydrogen or a hydroxy group, and R6 is hydrogen or a hydroxy group, or a non-toxic acid addition salt thereof, is useful in the parenteral treatment of visceral leishmaniasis or malaria, and a synergistic composition comprising a compound of formula (I) or a non-toxic acid addition salt thereof and sodium stibogluconate is useful in the treatment of visceral leishmaniasis.