the paramagnetic complex salts, preparation and application thereof in the nmr diagnostics.

摘要

1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Physiologically compatible paramagnetic complex salts of aminopolycarboxylic acids of the formulae I to IV see diagramm : EP0071564,P14,F1 N-Hydroxyethyl-N,N',N'-ethylenediaminetriacetic acid (HEDTA) see diagramm : EP0071564,P14,F2 N,N,N',N",N"-diethylenetriaminepentaacetic acid (DTPA) HOH2 C-CH2 N(CH2 COOH)2 N-Hydroxyethyliminodiacetic acid see diagramm : EP0071564,P14,F3 wherein m represents 1 to 4 n represents 0 to 2 R**1 represents a saturated or unsaturated hydrocarbon group with 4 to 12 hydrocarbon atoms or the group -CH2 -COOH, or diphosphonic acids of the general formula V see diagramm : EP0071564,P15,F1 wherein R2 represents hydrogen, alkyl of 1 to 4 carbon atoms, halogen, the hydroxy-, amino- or CH2 -COOH groups, and R3 represents hydrogen, alkyl of 1 to 4 carbon atoms, or the -CH2 -COOH group, and the ions of the lanthanide elements of numbers 57 to 70 or the ions of the transition metals of numbers 21 to 29, 42 and 44 and an organic base, by which as organic base glucamine, N-methylglucamine, N,N-dimethylglucamine, ethanolamine, diethanolamine, morpholine, lysine, ornithine and arginine are concerned. 1. Claims for the Contracting State : AT Process for the preparation of materials for NMR-diagnosis containing at least a paramagnetic, physiologically compatible complex salt of aminopolycarboxylic acids of the formulae I to IV see diagramm : EP0071564,P19,F1 N-Hydroxyethyl-N,N',N'-ethylenediaminetriacetic acid (HEDTA) see diagramm : EP0071564,P19,F2 N,N,N',N",N"-Diethylenetriaminepentaacetic acid (DTPA) HOH2 C-CH2 N(CH2 COOH)2 N-Hydroxyethyliminodiacetic acid see diagramm : EP0071564,P19,F3 wherein m represents 1 to 4 n represents 0 to 2 R**1 represents a saturated or unsaturated hydrocarbon group with 4 to 12 hydrocarbon atoms or the group -CH2 -COOH, or diphosphonic acids of the general formula V see diagramm : EP0071564,P20,F1 wherein R2 represents hydrogen, alkyl of 1 to 4 carbon atoms, halogen, the hydroxy-, amino- or CH2 -COOH groups, and R3 represents hydrogen, alkyl of 1 to 4 carbon atoms, or the -CH2 -COOH group, and the ions of the lanthanide elements of numbers 57 to 70 or the ions of the transition metals of numbers 21 to 29, 42 and 44 and an organic base, by which as organic base glucamine, N-methylglucamine, N,N-dimethylglucamine, ethanolamine, diethanolamine, morpholine, lysine, ornithine and arginine are concerned, optionally with the usual additives in the art, dissolved or suspended in water or physiological salt solution characterised in that one brings into a form for oral or intravascular application the paramagnetic complex salt dissolved or suspended in water or a physiological salt solution optionally with the usual additives in the art.