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Asymmetric synthesis of pyridine derivatives FURO3,4 C AND PHARMACEUTICAL PREPARATIONS NON-racemic, pharmaceutically active derivatives.
Asymmetric synthesis of pyridine derivatives FURO3,4 C AND PHARMACEUTICAL PREPARATIONS NON-racemic, pharmaceutically active derivatives.
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机译:吡啶衍生物FURO3,4 C的不对称合成和药物制剂非消旋,可药用的衍生物。
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摘要
The invention relates to a method for the preparation of a non-racemic furo [3,4-c] pyridine derivatives of the formula I IMAGE I wherein R1, R2 and R3 stand for various substitutents, comprising adding a concentrated strong acid to a solution of a non-racemic compound of the formula II IMAGE II in an amount sufficient to catalyze a deprotection/cyclodehydration. These compounds are known antihypertensives.
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