PURIFICATION OF LANTIBIOTICS BY TREATING THE FERMENTATION BROTH WITH A STYRENE COPOLYMER MATRIX, CATION EXCHANGE CHROMATOGRAPHY, HYDROPHOBIC INTERACTION CHROMATOGRAPHY AND DESALTING

摘要

A process for isolating and purifying a lantibiotic from a fermentation broth using a styrene-divinyl-copolymerisate matrix, a strong cation exchanger, means for hydrophobic interaction chromatography and preferably a weak anion exchanger.