3,4-DISUBSTITUTED PHENYL-1,4-DISUBSTITUTED CYCLOHEXANES OR CYCLOHEXENES USEFUL FOR TREATING PDE IV RELATED DISEASES

摘要

PCT No. PCT/US93/01988 Sec. 371 Date Sep. 29, 1994 Sec. 102(e) Date Sep. 29, 1994 PCT Filed Mar. 5, 1993 PCT Pub. No. WO93/19747 PCT Pub. Date Oct. 14, 1993Novel cyclohexane-ylidene derivatives of formula (I) are described. These compounds inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production. These compounds are also useful in the mediation or inhibition of enzymatic or catalytic activity of phosphodiesterase IV and are therefore useful in the treatment of disease states in need of mediation or inhibition thereof. IMAGE (I)