Anticalcification treatment for aldehyde-tanned biological tissue

摘要

A method of treating aldehyde-tanned biological tissue minimizes in vivo calcification and reduces cytotoxicity without impairing the mechanical strength of the tanned tissue. The method includes the step of treating the aldehyde-tanned biological tissue with at least one liquid polyol having the formula: IMAGE where R is CH2OH or an alkyl group, and R' is H, an alkyl group or an O-acyl where the acyl is C2-C9 or a carboxyalkyl; or IMAGE where R is H or an alkyl group, and R' is H, an alkyl group, O-alkyl or O-carboxyalkyl. Preferred polyols are propylene glycol, 1,3-propanediol, 2,3-butylene glycol and glycerol, and the polyol is preferably a diol.