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USE OF OXALYL-AMINOSE DERIVATIVES AS A MEDICINAL PRODUCT FOR THE INHIBITION OF PROLYL HYDROXYLASE.
USE OF OXALYL-AMINOSE DERIVATIVES AS A MEDICINAL PRODUCT FOR THE INHIBITION OF PROLYL HYDROXYLASE.
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机译:使用草酰氨基衍生物作为医药产品来抑制脯氨酰羟化酶。
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摘要
The invention relates to oxalylamino acid derivatives of the formula I IMAGE in which R and R' are identical or different and are C1-C6 -alkyl or hydrogen, R1 is hydrogen or C1-C4-alkyl, R2 is hydrogen, C1-C6-alkyl, C1-C3-alkoxy, carboxyl, C1-C6-alkoxycarbonyl, aryl, SH, NH2 or halogen, where the alkyl radicals are unsubstituted or substituted by aryl, OH, SH or NH2 or R1 and R2 together are a C2-C4-alkylene chain and the compounds in their predominantly pure D- and L-form and the physiologically tolerable salts. The compounds are distinguished as excellent inhibitors of prolyl hydroxylase and lysine hydroxylase.
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