active compounds on tissue forms of malaria and preparation process.

摘要

The invention relates to novel quinoline CONTAINING A function free amine and have anti-malarial properties, especially to novel primaquine or their addition salts with acid and process for their preparation. According to the invention, these new derivatives are schematically represented by the formula PQ-X, WHICH REPRESENTS PQ quinolines CONTAINING A function free amine and have anti-malarial properties, particularly primaquine; X represents an amino acid or peptide 2-4 amino acids; BEING THE UNION PQ-X a covalent bond between the Group AMINA peptidic FREE PQ AND THE GROUP carboxylic X, REMAIN STABLE THE UNION PQ-X in serum and lysosomal hydrolases RESISTANT. In one embodiment of the invention, the amino acid or the first amino acid peptide bound to PQ is acid (TAU) L-glutamic acid or acid (BETA) aspartic JOINED BY ITS GROUP PQ (TAU) - O (BETA )-carboxyl, OR L-pyroglutamic acid, aspartic acid KINGDOM OR A GROUP FOR YOUR PQ (ALFA)-carboxyl.