20,21-DINOREBURNAMENIN DERIVATIVES SUBSTITUTED IN C-15 BY AN AMINO GROUP AND THEIR SALTS, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES THUS OBTAINED, THEIR APPLICATION AS MEDICINE AND PHARMACEUTICAL COMPOUNDS CONTAINING THEM

摘要

ABSTRACT OF THE DISCLOSURE: The Compounds: (I) wherein R1 and R2, identical or different, repre-feel hydrogen, alkyl (C1-5) - (CH2) n-OH, (n = 2-5), aryl or aryl- (C7- 12), optionally substituted, a -? - R3 wherein R3 is alkyl (C1-5), aryl or arylalkyl (C7-12), optionally substituted, R1 and R2 can not both represent an aryl, or R1 and R2 form with the nitrogen a heterocycle possibly containing a second heteroatom such as oxygen, sulfur nitrogen, the latter optionally substituted, R4 and R5 are identical or different hydrogen, halogen, alkyl or alkoxy (C1-5), hydroxy, trifluoromethyl or nitro, process and intermediates for preparation, their use as medicaments and pharmaceutical compositions containing them.