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BCL-1 LOCUS NUCLEIC ACID PROBES AND ASSAY METHODS
BCL-1 LOCUS NUCLEIC ACID PROBES AND ASSAY METHODS
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机译:BCL-1局部核酸问题和评估方法
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摘要
BCl-1 LOCUS NUCLEIC ACID PROBES AND ASSAY METHODS Nucleic acid probes substantially complementary to nucleic acid sequences within the bcl-1 locus are disclosed as well as polymerase chain reaction (PCR) primers substantially complementary to nucleic acid sequences within that locus that are useful in detecting t(11;14)(q13;q32) translocations associated with hematopoietic cancers. Further, the bcl-1 locus probes are useful in detecting bcl-1 amplifications found in about twenty percent of solid tumors, particularly in squamous cell and mammary carcinomas. Diagnostic/prognostic methods for cancer are disclosed, as well as cancer research methods using the bcl-1 probes of this invention.
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