METHOD OF DESTABILIZATION OF THE SECONDARY INTRASTAND STRUCTURE OF A SIMPLE STRAND POLYNUCLEOTIDE, AND CAPTURE OF SAID NUCLEOTIDE

摘要

2134113 9419490 pctabs00167 process of destabilization of a secondary structure of a single stranded polynucleotide intracatu00e9naire and capture of a polynucleotide.is characterized by the fact that it is in contact with a device comprising an oligonucleotide on a support with a liquid phase containing the polynucleotide.at a temperature of less than 50 - c during the summer.playing the role of the oligonucleotide capture probe containing a sequence known as disruptive and hybridizing with a sequence not participating in the self complementary structureecondaire said polynucleotide; and device for implementing this process.