DERIVATED DTPA COMPLEXES, PHARMACEUTICALS CONTAINING THESE COMPOUNDS, THEIR USE AS NMR AND RADIOGRAPHIC CONTRASTING AGENTS AND PROCESS FOR PRODUCING THE SAME

摘要

Complex compounds and their salts consist of at least one metal ion and a complexing agent having general formula (I), in which Z1 and Z2 represent independently from each other a hydrogen atom, the residue -(CH2)m-(C6H4)q-(O)k- (CH2)n-(C6H4)l-(O)r-R, or the residue -(CH2)m-(C6H10)q-(O)k- (CH2)n-(C6H10)l-(O)r-R, in which m and n are the numbers 0-5, q, k, l and r are the numbers 0 or 1 and s is the number 1 or 2; R stands for a hydrogen atom, an if required OR1-substituted, straight-chain or branched-chain C1-C6-alkyl residue or a CH2-COOR1 group, in which R1 stands for a hydrogen atom, a C1-C6-alkyl residue or a benzyl group, with the proviso that one of the substituents Z1 or Z2 stands for a hydrogen atom and the other does not, and that a direct oxygen-oxygen bond is not allowed. Also disclosed is their use for producing radiotherapy agents and NMR and radiographic diagnosing agents, in particular for contrasting the hepatobiliary system. A process for producing these compounds and agents is further disclosed.