Monoclonal antibodies specific for 3',6'-isold1 ganglioside

摘要

Monoclonal antibodies which bind to the ganglioside IV3NeuAc, III6NeuAc-LcOse4Cer (3',6'-isoLD1), are disclosed, along with methods of making the same and diagnostic and therapeutic methods of using the same. Particularly preferred are monoclonal antibodies which bind to a 3',6'-isoLD1 epitope selected from the group consisting of NeuAc(alpha)2-3Gal(beta)1-3NeuAc(alpha)2-6GlcNAc and NeuGc(alpha)2-3Gal(beta)1-3NeuGc(alpha)2-6GlcNAc.