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Treatment of insulin resistance in obesity linked type ii diabetes using antagonists to tnf-alpha function
Treatment of insulin resistance in obesity linked type ii diabetes using antagonists to tnf-alpha function
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机译:使用tnf-alpha功能拮抗剂治疗肥胖相关的II型糖尿病患者的胰岛素抵抗
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摘要
An induction of TNF- alpha mRNA expression has been observed in adipose tissue from four different insulin resistant rodent models of obesity and diabetes. TNF- alpha protein was also elevated locally and systemically. Neutralization of TNF- alpha in obese fa/fa rats caused a significant increase in the peripheral uptake of glucose in response to insulin. A method of treating an animal suffering from insulin resistance in obesity linked Type II diabetes mellitus is disclosed. The method includes providing a therapeutic agent that includes an antagonist to TNF- alpha function in a pharmaceutically acceptable carrier substance and administering a pharmacologically effective amount of the therapeutic agent to the animal.
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