THE USE OF NITRIC OXIDE-DELIVERING COMPOUNDS FOR THE TREATMENT OR PREVENTION OF ALCOHOLIC LIVER INJURY

摘要

Nitric oxide-delivering compounds are administered to an individual for the treatment or prevention of liver disease induced by ingestion of alcohol, or exposure to pharmacological agents or industrial toxins. Examples of nitric oxide-delivering compounds include S-nitrosothiols, thionitrites, thionitrates, sydnonimines, furoxans, organic nitrates, nitroprusside, nitroglycerine, iron-nitrosyl compounds, or other related compounds. In addition alcohol-induced liver disease may also be prevented by administering a therapeutically effective amount of either arginine, an arginine analog, or a nitric oxide-delivering compound, in combination with an alocholic beverage which is to be consumed by an individual.