NEW NON-IONIC IODINE-CONTAINING DIMERS USEFUL AS X-RAYS CONTRAST AGENTS, METHOD FOR THE PREPARATION THEREOF, AND GALENICAL COMPOSITIONS CONTAINING THEM

摘要

The invention relates to new non-ionic iodine-containing X-rays contrast agents, having a dimer structure and general formula (I), where the union bridge is N-substituted azapentanediamide, wherein R1 and R7, similar or different, are a linear or branched C2-C4 polyhydroxyalkyl radical having from 1 to 3 OH groups; R2 and R6, similar or different, are hydrogen, methyl or 2-hydroxyethyl; R3 and R5, similar or different, are hydrogen or methyl; R4 is hydrogen, methyl, metoxymethyl or a linear or branched C2-C4 polyhydroxyalkyl radical having from 1 to 3 OH groups. The invention also refers to methods for the preparation of products having formula (I) as well as to pharmaceutical preparations which contain said products.