PRODUCTION OF RADIOIODINATED 1--G(B)-D-ARABINOFURANOSYL)-5(E)-(2-IODOVINYL)URACIL, AND USES THEREOF, AND RELATED ANALOGUES INCORPORATING ALTERNATIVE HALOGEN RADIONUCLIDES, THE GENERAL RADIOHALOGENATION PRECURSORS, 1-(2,3,5-TRI-O-ACETYL--G(B)-D-ARABINOFURANOSYL)-5(Z AND E)-(2-TRIMETHYLSILYLVINYL)URAC

摘要

anti radioactive compounds containing 1 - (beta - d-arabino - furanosyl) (5) (e) - (2 - [i] - uracil iodovinyl), described below, "[i] ivarau, as prototype for the class of compounds known as 1 - beta - arabinofuranosyl) (5) (e) - (2 - [*] - uracil, halogu00e9novinyl) following [*] and the new xvarau, precursor thereof, 1 - (3)5 - tri - n - acetyl - beta - arabinofuranosyl) - 5 (z, e) - (2) - trimu00e9thylsilylvinyl) uracil, listed below by tmsvarau, processes for the preparation of these compounds and the use of these formulas in which "i" refers to a radionuclide iodine and "x" refers to any radionuclide. alogu00e9nu00e9 appropriate.the inclusion of the appropriate gamma or positron) transmitter, or other appropriate radioncuclide "within the framework of [i] - ivarau makes this agent useful as a diagnostic tool for the detection of in vitro and in vivo infections due to herpes simplex virus.the inclusion of alpha emitting isotopes of iodine apropriu00e9s and / or beta / gamma, and / or associated with a decrease of auger electron (specifically nuclear toxic halogenated products, or other suitable structure of the agent, the agent is useful as a tool for single radiotherapeutic infections due to herpes simplex virus.for specific targeting of the lethal effects of radiation and / or alpha beta and / or auger electron decay effects at the site of the viral infection.