N-(2-Oxopyrrolidin-1-yl)-acetylpiperazine derivatives and drug for senile dementia

摘要

A compound of the formula: CHEM (wherein R is -SO2R1 or -CONHR2; R1 is C1-C5 alkyl, C8-C12 phenylalkenyl, amino, dimethylamino, optionally substituted C6-C12 aryl, or 5- or 6-membered heterocyclic group including at least one hetero atom selected from the group consisting of N, S, and O; R2 is amino, C1-C5 alkylamino, C1-C5 alkyl, or optionally substituted C6-C12 aryl) or its pharmaceutically acceptable acid-addition salt, being useful as a drug for senile dementia, psychotropic, or antiamnesia agent is provided through several routes.