Anti-ganglioside GD1a monoclonal antibody MZ, MZ-producing cells and MZ-containing reagent

摘要

Disclosed is a novel anti-ganglioside GD_1a mono­clonal antibody (MZ) which is capable of recognizing ganglioside GD_1a but is practically incapable of recog­nizing GalCer, LacCer, Gb₃, Gb₄, GA₁, GA₂, GM₁, GM₂, GM₃, GD_1b, GT_1b, GQ_1b, Fuc-GM₁, nLc₄ and sialosyl nLc₄; MZ-producing cells; an MZ-containing reagent; and a method for the detection or quantification of GD_1a using the reagent, e.g., to diagnose cancer, systematic lupus erythematosus and diseases resulting from organic injury of the nervous system.