Process for the production of crystalline forms of the lithium, potassium and magnesium salts of cytidindiphosphocholine, the crystalline forms thus obtained and their pharmaceutical use

摘要

A process for the production of crystalline forms of salts of cytidindiphosphocholine (cyticholine) with monovalent cations of lithium (Li⁺) and potassium (K⁺) and with the bivalent cation of magnesium (Mg⁺⁺) is described. The process comprises the salification of the cyticholine in its form of free acid with the oxides, hydroxides, carbonates or bicarbonates of their cations and the crystallization of the salts with acetone. The new crystalline forms obtained can be advantageously used in the treatment of the diseases of the nervous system.