SUBSTITUTED GUANIDINES AND DERIVATIVES THEREOF AS MODULATORS OF NEUROTRANSMITTER RELEASE AND NOVEL METHODOLOGY FOR IDENTIFYING NEUROTRANSMITTER RELEASE BLOCKERS

摘要

Neurotransmitter release modulators comprising substituted guanidines, N "-aminoguanidines, and hydrazinedicarboximidamides N, N ', N", N "' - tetrasubstituted as well as pharmaceutical compositions composed of these elements are described. use of such neurotransmitter release modulators for the treatment or prevention of pathophysiological conditions characterized by the release of excessive or insufficient levels of neurotransmitters. In addition, detection assays for compounds which selectively inhibit glutamate release are described. as methods of inhibiting tension-sensitive sodium and calcium in mammalian nerve cells.