8-METHYL-3-(2-MORPHOLINOETHYLTHIO)-5H-1,2,4-TRIAZINO5,6-BINDOLE DIHIDROCHLORIDE HYDRATE SHOWING CAPABILITY TO ACCELERATE RECOVERY OF CEREBRUM FUNCTION IN THE EARLY PERIOD AFTER ACUTE MICROWAVE THERMAL STRESS

摘要

FIELD: organic chemistry. SUBSTANCE: product: 8-methyl-3-(2-morpholinoethylthio)-5H-1,2,4-triazino[5,6-b] -indole dihydrochloride hydrate, gross-formula is C₁₆H₂₁Cl₂N₅OS·H₂O, yield is 40%, m.p. is 266 C. Reagent 1: 2,3-dihydro-8-methyl-5H-1,2,4-triazino[5,6-b] -indole-3-thione. Reagent 2: 2-morpholinoethylbromide hydrobromide. Reaction conditions: in aqueous medium in the presence of NaOH following by treatment of free base formed with hydrochloric acid in the medium of isopropyl alcohol. EFFECT: improved method of synthesis. 2 tbl, 1 ex