Process for the production of substantially pure non-perspiration-suitable polydesoxyribonucleotides with biological activities and a respectable product.

摘要

Prodn. of non-informational, pure polydesoxyribonucleotides (PDRN) having biological activities comprises (a) pulping the placenta of emochorial mammals; (b) thermal inactivation of endogenous desoxyribonucleases liberated during antolysis; (c) controlled proteolysis of the material; (d) sepn. of insoluble residue from the aq. phase; (e) sepn. of PDRN from the liq. by complexation with solid or liq. quat. bases or by salt formation with divalent metals; (f) purificn. of PDRN after decomplexation or elution with solns. of alkaline earth metal sa and (g) controlled partial depurinisation of native PDRN in order to eliminate the informational capability (viruses, onogenes). The SO obtd. PDRN are claimed characterised by anticomplement activity in vitro; inhibition of chemical mediators of inflammation in vitro; inhibition of inflammation due to corragheenin or foreign bodies; inhibition of leucocyte migration in vivo; and therapeutic activity on "cervico-vaginities, lesions, due to dithermocoagulation, extropion and transformations areas" (Si2).