new 4 oxobenzotriazine and 4 oxochinazoline.

摘要

Compounds of formula (I) and pharmaceutically acceptable salts thereof: CHEM wherein X is N or CH; R1 and R2 are the same or different and are hydrogen, halogen, CF3, C1-6 alkyl, C1-7 acyl, C1-7 acylamino, or amino, aminocarbonyl or aminosulphonyl, optionally substituted by one or two C1-6 alkyl or C3-8 cycloalkyl groups, or by C4-5 polymethylene or by phenyl, C1-6 alkylsulphonyl, C1-6 alkylsuphinyl, C1-6 alkoxy, C1-6 alkylthio, hydroxy or nitro; or R1 and R2 taken together are methylenedioxy or ethylenedioxy; Z is a group of formula (a), (b) or (c) CHEM CHEM wherein n is 2 or 3; p is 1 or 2; g is 1 to 3; r is 1 to 3; and R3 or R4 is C1-4 alkyl; having 5-HT3 receptor antagonist activity, a process for their preparation and their use as pharmaceuticals.