Polypeptides having a receiver activity of dopamine, nucleic acids encoding these polypeptides and use of these polypeptides for the screening of active substance (s) on these polypeptides.

摘要

The subject of the invention is new polypeptides having a dopaminergic receptor activity containing: @ the sequence of 446 amino acids of Figure 1, @ or a fragment of this sequence, this fragment being such that * either it contains, nevertheless, the sites contained in this sequence and whose presence is necessary so that, when this fragment is exposed at the surface of a cell, it is capable of binding dopamine, its agonists or antagonists specifically and measurably, for example by means of a radioactive ligand, * or it is capable of being recognised by antibodies which also recognise the abovementioned sequence of 446 amino acids, but recognise neither the domaminergic receptor D-1, nor the dopaminergic receptor D-2, * or it is capable of generating antibodies recognising the abovementioned sequence of 446 amino acids but recognising neither the dopaminergic receptor D-1, nor the dopaminergic receptor D-2. s