DNA encoding a pituitary-specific thyroid hormone receptor

摘要

The invention relates to the purification and cloning of a receptor for thyroid hormone. The receptor is designated PSTHR and is related to hormone receptors encoded by the genes erbA&agr;-1, erbaA&agr;- 2 and erbA&bgr;-1. The gene encoding PSTHR, erbA&bgr;-2, is partially homologous to the erbA&bgr;-1. However, PSTHR differs from the product of erbA&bgr;-1 in that its expression is limited to the anterior pituitary gland. The invention additionally concerns the uses for PSTHR in the diagnosis and therapy of human conditions.