Processes for the synthesis of 3-(substituted indolyl-2-yl) propenaldehydes

摘要

For utilizing, as intermediate, formula R.sub.1 R.sub.2 N--CHO and CH.sub.The method of the oxalyl chloride or bromide and compound synthesis formula ##STR1## compounds of 2& boxH; CH--O--R.sub.10 be the method utilized for synthesizing formula ##STR2## compounds, as intermediate, compounds of formula I wherein R.sub.1 is phenyl or replaces phenyl or reconcile that wherein mesosome has following structure formula ##STR3## in middle synthesis compounds of formula I, wherein R.sub.1 is C.sub.1-3 alkyl, phenyl or phenyl, by 1 to 3 substituent group C.sub.1-3 alkyl, C.sub.1-3 alkoxy, fluorine, chloro, bromine or nitro (maximum of two nitros) , & lt are independently each substitutions; P&gt ; & lt ; P&gt ; R. sub.2 be C.sub.1-3 alkyl , & P&gt ; & lt ; P&gt ; R.sub.10 be C. sub.1-6 alkyl , & P&gt ; & lt ; P&gt ; X.sup.& ominus ; It is chloride or bromide, Yi Ji & P&gt ; & lt ; P&gt ; R.sub.3-R.sub.6 such as specification.Defined & P&gt ; & lt ; P&gt ; Compounds of formula II is the intermediate in the synthesis of known HMB-CoA reductase inhibitors, inhibits the biosynthesis of cholesterol and acts on behalf of as antihyperchloesterolemic useful.