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Method of using human neurokinin-1 receptor short form
Method of using human neurokinin-1 receptor short form
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机译:使用人神经激肽-1受体短形式的方法
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摘要
A novel recombinant human neurokinin-1 receptor short form (hereinafter identified as human NK1R sF) is disclosed which has been prepared by polymerase chain reaction techniques. Also disclosed is the complete sequence of human NK1R sF complementary DNA; expression systems, including a CHO (Chinese hamster ovarian cell line) stable expression system; and an assay using the CHO expression system.PP NK1R sF, can be used in an assay to identify and evaluate entities that bind substance P receptor or NK1R sF. The assay can also be used in conjunction with diagnosis and therapy to determine the body fluid concentration of substance P antagonists in arthritis patients.
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机译:公开了通过聚合酶链反应技术制备的新型重组人神经激肽-1受体短形式(以下称为人NK1R sF)。还公开了人NK1R sF互补DNA的完整序列。表达系统,包括CHO(中国仓鼠卵巢细胞系)稳定表达系统; P NK1R sF可以用于鉴定和评估结合P受体或NK1R sF的实体。该测定法还可以与诊断和治疗结合使用以确定关节炎患者中P物质拮抗剂的体液浓度。
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