METHOD OF TREATING RECURRENT MISCARRIAGE AND IMPROVING THE EFFICACY OF ASSISTED REPRODUCTIVE TECHNIQUES USING PLACENTAL PROTEIN 14

摘要

A method of preventing miscarriage in a female by administering to the female a therapeutically effective amount of an active substance selected from the group consisting of PP14, derivatives of PP14, muteins of PP14, fragments of PP14, and subunits of PP14, so as to prevent miscarriage. A method of testing a female for the possibility of future miscarriage by measuring the level of PP14 in the female, and comparing the measured level to the level of PP14 present in normal fertile women. A method of improving the efficacy of assisted reproductive techniques such as artificial insemination, in-vitro fertilization, or gamete intra-fallopian transfer, by adding an effective amount of PP14 to a sample comprising an embryo, fertilized or unfertilized egg, mixture of eggs and sperm, or sperm alone, prior to, concurrently with, or following introduction of the sample into the patient.