The blood platelet cohesion restrainer and the 5 ripokishigena - ze inhibiter null which designate the new do - pamin derivative and the said derivative as the

摘要

NEW MATERIAL:A compound expressed by the formula (R is undecyloyl, stearoyl, oleoyl, linoleoyl or linolenoyl). EXAMPLE:N-Undecyloyl dopamine. USE:A blood platelet aggregation-inhibiting agent and 5-lipoxygenase inhibitor. Useful for remedy for cerebral infarction, cerebral thrombosis, arteriosclerosis, stenocardia, bronchial asthma and allergic disorder. Low in toxicity and high in safety. PREPARATION:A fatty acid carboxylic acid expressed by the formula RCOOH is reacted with dopamine hydrochloride in a solvent such as THF, etc., in the presence of a base (e.g. triethyl amine) and a peptide synthetic reagent (e.g. isobutyl chlorocarbonate) at 0 deg.C - room temperature to provide a compound expressed by the formula.