CHEMICAL TO TREAT DISEASE THAT SHOWS INTERLEUKIN-6 SERUM CONCENTRATION ASCENDING SYMPTOM

摘要

PURPOSE: To obtain an agent containing interleukin-1(IL-1)-antagonist used for treating diseases associated with elevated serum interleukin-6 level. CONSTITUTION: This medicine contains IL-antagonist, e.g. an anti-IL-1-antibody, IL-1-receptor, IL-1-binding protein or IL-1-derivative containing IL-1-receptor, but not exhibiting IL-1 activity. The medicine is used for treating diseases exhibiting elevation of serum interleukin-6 level. The medicine exhibits high therapeutic effect on septic infection patients having IL-6 serum level value (normally =20 pg/ml) exceeding 1,000 pg/ml. IL-1-antagonist is advantageously applied in a total dose of 0.1-100 mg/kg, preferably 0.1-10 mg/kg.weight per 24 hr, as necessary, in divided portions or as a continuous injection and as necessary, over therapeutic period of several days until desired effect is attained.