3,4-DIHYDRO-1-(2-HYDROXYPHENYL)-2(1H)-QUINOXALINONE DERIVATIVE AND ITS RELATED COMPOUND

摘要

PURPOSE: To obtain a new quinoxalinone derivative useful as a thereapeutic agent for circulatory diseases, low in adverse action and having excellent vasodilating action and hypotensive action based on its smooth muscle relaxing action. ;CONSTITUTION: A compound of formula I [A is O, carbonyl, NR¹ (R¹ is H, a lower alkyl, etc.); B is NR² or CR³R⁴ (R² is H, a lower alkyl, etc., R³ and R⁴ are H, a hydroxy-substituted lower alkyl, etc.); W is O or S; X¹ and X² are H, a halogen, trifluoromethyl, nitro, cyano, etc.; Y¹ is H, a halogen or nitro; Y² is H, or Y² and Y³ are bonded to form naphthalene ring; Y³ is H, a halogen, CF₃, phenyl, etc.; Y⁴ is H, a lower alkyl, etc.; Z is H, a lower alkyl, etc.] such as 1-(5-chloro-2-hydroxyphenyl)-3,4-dihydroxy-6-trifluoromethyl-2(1H)- quinoxalinone. The compound of formula I is obtained, for example, by subjecting a compound of formula II (A¹ is O or NH; R³¹ is H or a lower alkyl; R⁴¹ is H, a lower alkyl, etc.; L¹ is amino, etc.; X¹¹ and X²¹ are H, a halogen, etc.) to ring closure.;COPYRIGHT: (C)1995,JPO