Process for inhibiting activity of tissue factor for inhibition of platelet storage for inhibition of vascular restenose and for treatment of acute occlusion of a coronary artery

摘要

The catalytic active site of Factor VII is modified to produce a compound which effectively interrupts the blood coagulation cascade. The modifications render Factor VIIa substantially unable to activate plasma Factors X or IX. Pharmaceutical compositions of the modified Factor VII are used to treat a variety of coagulation-related disorders.