THE USE OF DOPAMINE AND PROLACTIN STIMULATOR ANTAGONIST FOR PREPARING A PHARMACEUTICAL PREPARATION AND THE PHARMACEUTICAL PREPARATION ITSELF

摘要

A process for the long term modification and regulation of lipid and carbohydrate metabolism - generally to reduce obesity, insulin resistance, and hyperinsulinemia and hyperglycemia, or both (these are the hallmarks of noninsulin dependent, or Type II diabetes) - by administration (i.e., by oral, sublingual or parenteral administration) to a vertebrate, animal or human, of a dopamine agonist, e.g., bromocriptine. Administration of the bromocriptine is made over a limited period at a time of day dependent on the normal circadian rhythm of insulin resistant and insulin sensitive members of a similar species. Insulin resistance, and hyperinsulinemia and hyperglycemia, or both, can be controlled in humans on a long term basis by such treatment inasmuch as the short term daily administration resets hormonal timing in the neural centers of the brain to produce long term effects.