PHARMACEUTICAL PREPARATION FOR BONE MATTER LOSS INHIBITION

摘要

A method of inhibiting bone loss comprising administering to a human in need of treatment an effective amount of a compound having the formula CHEM wherein R is hydrogen; hydroxy; C1-C6 alkoxy; a group of the formula -O-C(O)-Ra, wherein Ra is hydrogen, C1-C6 alkyl optionally substituted with amino, halo, carbonyl, C1-C6 alkoxycarbonyl, C1-C7 alkanoyloxy, carbamoyl and/or aryl; or Ra is C1-C6 alkenyl optionally substituted with aryl; or Ra is a C3-C7 cycloalkyl; or Ra is aryl optionally substituted with hydroxy, C1-C6 alkyl, C1-C6 alkoxy, and/or halo; or Ra is -O-aryl, said aryl optionally substituted with hydroxy C1-C6 alkyl, C1-C6 alkoxy, and/or halo, or R is a group of the formula -O-SO2-Rb wherein Rb may be C1-C6 alkyl or aryl optionally substituted with C1-C6 alkyl; or R is carbamoyloxy wherein the nitrogen may be substituted once or twice with C1-C6 alkyl; or R is a group of the formula -O-C(O)Rc-O-(C1-C6 alkyl) wherein Rc is a bond or C1-C6 alkanediyl; R1 is halo, C1-C6 alkyl, C1-C7 alkyl substituted with C1-C6 alkyl, substituted or unsubstituted C3-C7 cycloalkyl, or substituted or unsubstituted C3-C7 cycloalkenyl; R2 is O or CH2; R3 is CH2 or (CH2)2; R4 is CHEM CH2, or a bond; and R5 is amino, nitrilo optionally substituted once or twice with C1-C6 alkyl; or an N-heterocyclic ring which optionally has another hetero atom selected from N, O, or S in said ring; or a pharmaceutically acceptable salt or solvate thereof.