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SELF-STABILIZED OLIGONUCLEOTIDE AND INHIBITION METHOD OF VIRUS GENE OR PATHOGENIC ORGANISM OR CELLULAR GENE EXPRESSION
SELF-STABILIZED OLIGONUCLEOTIDE AND INHIBITION METHOD OF VIRUS GENE OR PATHOGENIC ORGANISM OR CELLULAR GENE EXPRESSION
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机译:病毒基因或病原微生物或细胞基因表达的自稳定寡核苷酸和抑制方法
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摘要
The invention provides improved antisense oligonucleotides that are resistant to nucleolytic degradation. Such oligonuclotides are called self-stabilized oligonucleotides and comprise two regions: a target hybridizing region having a nucleotide sequence complementary to a nucleic acid sequence that is from a virus, a pathogenic organism, or a cellular gene; and a self-complementary region having an oligonucleotide sequence complementary to a nucleic acid sequence that is within the self-stabilized oligonucleotide.
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