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15-deoxyspergualin analogues, method for their preparation and their use in medicine
15-deoxyspergualin analogues, method for their preparation and their use in medicine
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机译:15-脱氧精瓜林类似物,其制备方法及其在医学中的用途
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摘要
15-deoxy-spergualin analogues of formula (I) and their addn. salts are new. X = (CH2)n; Y = (CH2)4; T = (CH2)2; A = a single bond, -CH2-, -CH2O-, -CH2NH-, -CH(OH)-, -CHF-, or -CH(OCH3)-; n = 6-8. Intermediate cpds. of formula (II) are also claimed. A has the values above or in addn. is CH(OCH2C6H5); R1, R2, R3 = amino-protective gps. of alkoxycarbonyl, benzyloxycarbonyl or benzyl type.
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机译:式(I)的15-脱氧-精豆素类似物及其加成物。盐是新的。 X =(CH2)n; Y =(CH2)4; T =(CH2)2; A =单键,-CH 2-,-CH 2 O-,-CH 2 NH-,-CH(OH)-,-CHF-或-CH(OCH 3)-; n = 6-8。中级cpds。还要求保护式(II)的化合物。 A的值大于或等于addn。是CH(OCH2C6H5); R1,R2,R3 =氨基保护gps。烷氧基羰基,苄氧基羰基或苄基类型的化合物。
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