PROCESS FOR PRODUCING DICOBALT-HEXACARBONYL COMPLEXES OF BICYCLO 7.3.1TRIDEC-4-ENE-2,6-DIYNE DERIVATIVES

摘要

The present invention relates to a novel and efficient process for the preparation of 8-hydroxy-bicyclo[7.3.1]-tridec-4-ene-2,6-diyne ring system which is part of the aglycone of esperemicin and to novel cytotoxic agents having said bicyclic ring system. The present invention also provides a method for treating animal malignant tumors by administering to an animal in need of such treatment an antitumor effective amount of a compound having the formula CHEM p