Compositions for reducing fluctuations in plasma¹concentrations of large neutral amino acids and use thereof¹in therapy

摘要

Nutritionally complete food product compositions are provided which have a ratio of carbohydrate to protein of from greater than 6:1 to less than 8:1, preferably 7:1, the protein component having protein efficiency ratio (PER) of greater than or equal to 2.5. The compositions are used to reduce fluctuations in plasma concentrations, especially post-prandial fluctuations, of large neutral amino acid (LNAA) levels and have particular use in the treatment of individuals suffering from Parkinson's Disease to reduce the variability of the individuals' response to a LNAA drug such as L-dopa, -methyldopa or 5-hydroxytryptophan. The compositions can be in the form of liquid formulations, including soups, and reconstitutable powders for forming such formulations, snack bars, entrees and desserts.