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N-SUBSTITUTED ב-ARYL- AND ב-HETEROARYL-א-CYANOACRYLAMIDE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING
N-SUBSTITUTED ב-ARYL- AND ב-HETEROARYL-א-CYANOACRYLAMIDE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING
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机译:N-取代的邻芳基和邻杂芳基-א-氰基酰胺基衍生物,它们的制备和包含的药物成分
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PCT No. PCT/EP95/00758 Sec. 371 Date Nov. 21, 1995 Sec. 102(e) Date Nov. 21, 1995 PCT Filed Mar. 2, 1995 PCT Pub. No. WO95/26341 PCT Pub. Date Oct. 5, 1995The present invention relates to new compounds of formula IMAGE (I) wherein A is a bicyclic ring chosen from naphthalene, tetrahydronaphthalene, quinoline, isoquinoline and indole. B is a R2 substituted benzene ring or an unsubstituted pyridine or thiophene ring; R is hydrogen, C1-C6 alkyl, halogen, nitro, cyano, carboxy or a group NR3R4 wherein each of R3 and R4 is independently hydrogen or C1-C6 alkyl; R1 is hydrogen, C1-C6 alkyl or C1-C6 alkanoyl; R2 is hydrogen, C1-C6 alkyl, halogen, nitro, cyano, carboxy, hydroxy, C1-C6 alkoxy, C1-C6 alkanoyloxy or a group NR3R4 wherein R3 and R4 are as defined above; n is zero or an integer of 1 to 2; x is zero or an integer of 1 to 5; and the pharmaceutically acceptable salts thereof. The compounds of the invention are useful as tyrosine kinase inhibitors.
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