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Wild-type multiple tumour suppressor (MTS) gene and mutant sequences-useful in diagnosis, prognosis and therapy of human cancer e.g. melanoma or leukaemia
Wild-type multiple tumour suppressor (MTS) gene and mutant sequences-useful in diagnosis, prognosis and therapy of human cancer e.g. melanoma or leukaemia
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机译:野生型多重肿瘤抑制基因(MTS)和突变序列-可用于人类癌症的诊断,预后和治疗黑色素瘤或白血病
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摘要
The present invention relates to somatic mutations in the Multiple Tumor Suppressor (MTS) gene in human cancers and their use in the diagnosis and prognosis of human cancer. The invention further relates to germ line mutations in the MTS gene and their use in the diagnosis of predisposition to melanoma, leukemia, astrocytoma, glioblastoma, lymphoma, glioma, Hodgkin's lymphoma, CLL, and cancers of the pancreas, breast, thyroid, ovary, uterus, testis, kidney, stomach and rectum. The invention also relates to the therapy of human cancers which have a mutation in the MTS gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.
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